Carlotta De Filippo, Senior Researcher at the National Research Council (CNR, Italy), explores diet’s health effects and disease prevention. Early in her career, she studied antioxidants’ impact on colonic cancer development, revealing genetic triggers in preneoplastic lesion formation and diet’s role in cancer. Training at Harvard School of Public Health enriched her ability to investigate global diet-metabolism links through DNA microarrays, pioneering Nutrigenomics/Toxicogenomics in Italy. Since 2009, she has focused on gut microbiome variation, linking diet and microbiota diversity to metabolism. Her work gained international recognition, resulting in impactful publications and EU project leadership (EIT-Food, JPI-HDHL and PRIMA). She has also delved into the diet-microbiota-inflammatory bowel disease nexus, utilizing metagenomics, metabolomics, and bioinformatics. De Filippo is author of 86 peer-reviewed full-papers, with an H-index of 37. She is a member of the Board of the Italian Society of General Microbiology and Microbial Biotechnologies. Furthermore, she serves as an expert evaluator for the European Food Safety Authority (EFSA) and for FAO (Memorandum of Understanding).